activity (Total 66456 Patents Found)

A pyrimidine derivative of formula (I) or (I′): wherein: R x is a substituent as defined within; Q 1 is optionally substituted phenyl, and Q 1 bears a substituent of formula (Ia) wherein: X, Y 1 , Y 2 , Z, n, and m are as defined within; —NQ 2 is an optionally substituted heterocyclic moiety containing one hydr...
A zinc oxide powder having a suppressed photocatalytic activity and prepared by coating a zinc oxide powder with at least one silicone compound in a nongaseous state and firing the coated zinc oxide powder in an oxidizing atmosphere at a temperature of 600 to 950° C. A cosmetic preparation containing this zinc oxide p...
The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula: ##STR1## wherein R 1 is hydrogen or amin...
In general, the invention is directed to identification of intrinsic ventricular activity occurring within a ventricular signal. In particular, the invention involves the analysis of ventricular signal morphology to determine if the signal contains intrinsic ventricular activity while delivering pacing pulses separated...
A security system and method of operation thereof stores information related to a plurality of detected events and determines an activity pattern based on the stored information. The system and method then determines a type of alarm, if any, to issue in response to a detected trigger event based at least in part on the...
The partial androgen deficiency of the aging male (PADAM) and the supplement of synthetic testosterone is an important research subject in the American biological science. The activity of leydigs cells of testis and the synthesizing and excreting state of testosterone has aroused wide concern of the medical circles. Ta...
The present invention relates to inhibition of viruses, e.g., HIV using oxindoles and compounds related to oxindoles. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy re...
Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of the desmethyl-vancomycin scaffold, in particular, acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring o...
From an enzymatic hydrolysate of bovine casein there was isolated a decapeptide whose sequence could be clearly identified in the primary sequence of the casein. This decapeptide, which was also prepared by synthetic chemistry, influences the growth of the insect cell line IPLB-Sf-21 in a concentration-dependent manner...
The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zinzeber officinale extract to improve the bioavailability of a wide variety of drugs....
Disclosed are compounds of the formula (I): wherein R 3 , R 4 , R 5 , R 9 , and R 10 are selected from the group consisting of H and groups or atoms other than H, and R 6 and R 8 are halo or hydrogen; X 1 , X 2 , and X 3 are independently O or S; provided that R 9 and R 10 are not simultaneously H, when all of X ...
Assay methods are disclosed having utility in the identification of therapeutic agents effective against human hepatitis C virus and related viruses. NS3 protein derived from these viruses, representing a native and authentic version of the complete protein sequence, is used in the assay methods of the invention, which...
The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI), their preparations and the methods of using these compounds or their pharmaceutically acceptable salt in the treatment of ce...
Sulfonamide and urea compounds having an inhibitory effect on Src kinase including enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates of said compound, said compound having the general structure shown in Formula II are disclosed and claimed:...
The invention provides bicyclic sulfone compounds, pharmaceutical compositions, methods of inhibiting RORy activity, reducing the amount of iL-17 in a subject, and treating immune disorders and inflammatory disorders using such bicyclic sulfone compounds. Another aspect of the invention provides a method of treating a ...
Disclosed are compounds of Formula A-a, or a salt thereof: Where “B 1 ” and “R 1 ” through “R 5 ” are as defined herein, which compounds have properties for blocking Na v 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of...
Example methods and systems for determining media files based on activity levels are described. An example method includes receiving information indicative of a first speed of the computing device, and receiving information indicative of a geography of a location of the computing device. The method further includes det...
An implantable medical device includes an activity sensor, a pulse generator, and a control module. The control module is configured to determine activity metrics from the activity signal and determine an activity metric value at a predetermined percentile of the activity metrics. The control module sets a lower pacing...
Various sensor systems are described herein, including inserts having sensors thereon, which are configured to be received in an article of footwear. The inserts may be connected to a sole member of the footwear, or may function as a sole member. The sensors may be bonded to an outer surface of the insert, or positione...
Embodiments include method, systems and computer program products for identifying unusual activity in an IT system based on user configurable message anomaly scoring. Aspects include receiving a message stream for the IT system and selecting a plurality of messages from the message stream that correspond to an interval...
A system or method can facilitate source localization of brain electrical activity. In one example, an expert system can be utilized to evaluate the source localization results and, based on the acceptability of the results, adjust a data preparation phase to provide for acceptable source localization....
The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above....
Methods and related systems for modulating neural activity by cyclically blocking conduction in peripheral neural structures are disclosed. In an aspect, neural activity is blocked cyclically with a blocking stimulus source positioned adjacent a skin surface in a vicinity of a nerve. Neural modulation may be used, for ...
This invention relates generally to chemically modified oligonucleotides useful for modulating activity of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonucleotides for inhibiting microRNA and pre-microRNA activity and to methods of making and using th...
A mobile communications fraud detection system is provided in which one or more probe devices are deployed to intercept predetermined types of data being carried over selected interfaces within the mobile communications network. In particular, the probe devices are arranged to intercept data being carried between equip...
The invention deals with the use of cysteine, a cysteine precursor substance or a cysteine derivative or a cysteine-containing substance to increase the oxygen supply to the tissue by increasing the ventilatory activity and/or by increasing the production of the blood-forming hormone erythropoietin (EPO), especially fo...
An apparatus and method for detecting the presence of a finger on a fingerprint sensor is disclosed in one embodiment of the invention as including transmitting a probing signal, comprising a series of probing pulses, to a fingerprint sensing area. A response signal, comprising a series of response pulses, is received ...
A novel ascomycetous Xylogone ganodermophthora strain has antifungal activity. A composition includes the strain as an active ingredient for preventing plant diseases. A method for producing the composition includes culturing the strain, and a method for preventing plant diseases includes using the strain. The strain...
Novel monoclonal antibodies that specifically bind to KAAG1 are described. In some embodiments, the antibodies block the biological activity of KAAG1 and are useful in composition in certain cancers, more particularly in cancers that have increased cell surface expression of KAAG1, such as ovarian, renal, lung, colorec...
A method, apparatus, and system for tracking row and object database activity into block level heatmaps is provided. Database activity including reads, writes, and creates can be tracked by a database management system at the finest possible level of granularity, or the row and object level. To efficiently record the t...
A method, comprising detecting an epileptic event in a neural network, wherein the event occurs in a first node; identifying a second node; and applying a therapy to the second node or any connection. A method, comprising determining a first body index indicative of epileptic activity; monitoring a second body index; d...
This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the ...
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G 1 , R 2 , R 3 , R 4 , R 5 , n, p, q, Ar 1 , and Ar 2 are defined in the description. The presen...
The present invention relates to methods of using meso-1,2,3,4-tetrahydroxybutane for the maintenance and/or improvement of biological cell function and activity, and for the prevention of improper cell functioning or cell death, in vitro, ex vivo, and in vivo over time and/or during exposure to stress. Meso-1,2,3,4-te...
Disclosed are 2-methylene analogs of vitamin D 3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylene-vitamin D 3 , (20S)-1α-hydroxy-2-methylene-vitamin D 3 , and (5E)-1α,25-dihydroxy-2-methylene-vitamin D 3 , their ...
The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides....
Described herein are systems and methods for performing operations responsive to potentially malicious activity. Embodiments may include receiving an indication of the potentially malicious activity in a computer network; identifying, based on data included in the indication, at least one network account associated wit...
The present invention relates to novel crystalline forms of salts of 2-((1R,4R)-4-(4-(5-(benzo[d]oxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl)acetic acid and their use in the treatment or prevention of a condition or a disorder associated with DGAT1 activity in animals, particularly humans....
A low overhead voice activity detection technique for a noise-canceling bioacoustic sensor consumes, as inputs, signals generated by a body microphone and an environment microphone and produces, as an output based on these inputs, an indication of whether voice activity is present. The technique applies a novel dual AN...